Here are the best psoriasis treatment creams on the market.
Why Some Creams Are Cutting-Edge
Thanks to improved formulations and skin-friendly ingredients, today's top creams deliver fast relief, are gentle on the skin, and can be used more consistently without irritation.
They are designed for everyday comfort and support, helping you feel better sooner.
So you can get back to your life with greater ease, not just manage symptoms.
Top Psoriasis Treatment Creams Making Waves
1. CeraVe Psoriasis Moisturizing Cream
A dermatologist-favorite, this over-the-counter formula contains salicylic acid to help reduce scales and azelainic acid to calm irritation, all in a rich, hydrating base with ceramides. Its gentle yet effective approach helps restore the skin barrier without stripping moisture—perfect for regular use.
2. MG217 Psoriasis Medicated Moisturizing Cream
This accessible OTC cream has stood the test of time. It combines coal tar—a classic anti-itching, anti-scaling ingredient—with modern moisturizing agents. Many users say it's a reliable first line of defense for mild to moderate flares.
3. Elidel (pimecrolimus) Cream
Now widely prescribed, Elidel is a non-steroidal topical immunomodulator. It actively reduces inflammation and itching by blocking certain immune reactions in the skin, and it's especially helpful for sensitive areas like the face or skin folds where steroids aren’t ideal.
4. Tacrolimus (Protopic) Ointment
Similar to Elidel in action, tacrolimus is another non-steroid option that calms inflammation with fewer long-term side effects than potent topical steroids. It’s often recommended when flares occur in delicate or thin-skinned regions.
5. Vectical (calcipotriene) Cream or Ointment
A vitamin D analog, Vectical gently slows down the rapid skin cell turnover characteristic of psoriasis. It’s frequently recommended as a maintenance therapy—ideal for use during times when your skin needs a lighter, preventive touch.
Why These Creams Are Game-Changers
- Range of options: From non-prescription moisturizers to prescription immunomodulators and vitamin D analogs, there’s a match for every severity level and skin type.
- Improved tolerability: Modern formulas aim to reduce side effects like burning, burning, or thinning skin, making long-term use more comfortable.
- Flexibility in skincare routines: These creams can often be layered with gentle moisturizers or used with phototherapy or systemic treatments when needed.
The Lifestyle Advantage
These creams feel less “medicated” and more like skincare—absorbing quickly, smelling neutral, and fitting naturally into your daily routine. That means you're more likely to use them consistently—a key element in managing flare-ups and maintaining results.
References
- American Academy of Dermatology — Psoriasis: Diagnosis and treatment (including topical options like vitamin D analogs, tacrolimus, and topical steroids)
(aad.org) - National Psoriasis Foundation — Topical Treatments overview, including OTC and prescription creams like calcipotriene, tacrolimus, and coal tar
(psoriasis.org)
